| http://purl.uniprot.org/citations/19722042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19722042 | http://www.w3.org/2000/01/rdf-schema#comment | "We evaluated the frequency, demographic, clinical, disability evolution and genetic association of HLA DRB1*1501, DRB1*1503, DQA1*0102, DQB1*0602 and DPA1*0301 alleles in patients diagnosed as acute disseminated encephalomyelitis (ADEM) among a population of CNS demyelinating diseases. Fifteen patients (8.4%) of our series were diagnosed as ADEM. The mean age onset was 35.23 years (range 12 to 77), 53.3% were male and follow-up range was 8.5 to 16 years. Two cases (13.3%) had a preceding infection before neurological symptoms, one presented a parainfectious demyelinating, and one case had been submitted to hepatitis B vaccination four weeks before the clinical onset. The EDSS range was 3.0 to 9.5. Eight patients (53.3%) presented MRI with multiple large lesions. CSF was normal in 73.3%. The severe disability observed at EDSS onset improved in 86.66% patients. The genetic susceptibility for ADEM was significantly associated with the HLA DQB1*0602, DRB1*1501 and DRB1*1503 alleles (<0.05) in monophasic ADEM."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.org/dc/terms/identifier | "doi:10.1590/s0004-282x2009000400013"xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Quirico-Santos T."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Alves-Leon S.V."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Alvarenga M.P."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Frugulhetti I."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Gaspareto E.L."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Gouveia M.E."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Malfetano F.R."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/author | "Veluttini-Pimentel M.L."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/name | "Arq Neuropsiquiatr"xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/pages | "643-651"xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/title | "Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study."xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/19722042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19722042 |
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