| http://purl.uniprot.org/citations/19722192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19722192 | http://www.w3.org/2000/01/rdf-schema#comment | "Pleckstrin (plek)-null platelets from a knockout mouse have been shown to be defective in granule secretion, aggregation and actin polymerization. However, the mechanism of plek signaling is currently unknown. Therefore, we sought to identify plek-binding proteins in platelets by using GST pulldown assays and immunoprecipitation to isolate proteins from extracts of protein kinase C-activated or inhibited human platelets. Co-purified plek-binding proteins were resolved by SDS-PAGE and identified via nanospray quadruple TOF MS. Identified proteins may be involved in various cellular processes including cytoskeletal reorganization (moesin, radixin and alpha-actinin) and signal transduction (serum deprivation response protein, 17 beta-hydroxysteroid dehydrogenase 4 and factor XIIIA). Both platelet aggregation and/or secretion require actin polymerization. However, studies have shown no direct association between plek and actin. Based on our findings we propose indirect associations between plek and actin through 17 beta-hydroxysteroid dehydrogenase 4, alpha-actinin, moesin, radixin and factor XIIIA, which in turn suggest new roles for plek in platelet biology."xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.org/dc/terms/identifier | "doi:10.1002/pmic.200900060"xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/author | "Haslam R.J."xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/author | "Bao X."xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/author | "Baig A."xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/name | "Proteomics"xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/pages | "4254-4258"xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/title | "Proteomic identification of pleckstrin-associated proteins in platelets: possible interactions with actin."xsd:string |
| http://purl.uniprot.org/citations/19722192 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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