| http://purl.uniprot.org/citations/19722284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19722284 | http://www.w3.org/2000/01/rdf-schema#comment | "Domain 4 of the anthrax protective antigen (PA) plays a key role in cellular receptor recognition as well as in pH-dependent pore formation. We present here the 1.95 A crystal structure of domain 4, which adopts a fold that is identical to that observed in the full-length protein. We have also investigated the structural properties of the isolated domain 4 as a function of pH, as well as the pH-dependence on binding to the von Willebrand factor A domain of capillary morphogenesis protein 2 (CMG2). Our results provide evidence that the isolated domain 4 maintains structure and interactions with CMG2 at pH 5, a pH that is known to cause release of the receptor on conversion of the heptameric prepore (PA(63))(7) to a membrane-spanning pore. Our results suggest that receptor release is not driven solely by a pH-induced unfolding of domain 4."xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.org/dc/terms/identifier | "doi:10.1002/pro.238"xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/author | "Anbanandam A."xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/author | "Lovell S."xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/author | "Williams A.S."xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/author | "Bann J.G."xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/author | "El-Chami R."xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/name | "Protein Sci"xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/pages | "2277-2286"xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/title | "Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH."xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/19722284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19722284 |
| http://purl.uniprot.org/citations/19722284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19722284 |
| http://purl.uniprot.org/uniprot/#_P13423-mappedCitation-19722284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19722284 |
| http://purl.uniprot.org/uniprot/P13423 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19722284 |