| http://purl.uniprot.org/citations/19723502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19723502 | http://www.w3.org/2000/01/rdf-schema#comment | "B7-H4, a newly identified B7 family molecule, is reported to regulate T cell activation. However, the expression and function of B7-H4 remain controversial. Here, we demonstrated that B7-H4 expression in immune cells was undetectable at both the transcription and cell-surface protein levels. B7-H4 transfectants augmented anti-CD3 mAb-induced re-directed cytotoxicity and this was inhibited by anti-B7-H4 mAb. In a hapten-induced contact hypersensitivity model, treatment with anti-B7-H4 mAb at sensitization, but not at challenge, efficiently suppressed the ear swelling and CD8(+) T cell activation assessed by CD25 expression and IFN-gamma production. We found that cells expressing B7-H4 secreted soluble B7-H4 and the serum B7-H4 level increased with disease progression in lupus-prone and collagen-induced arthritis autoimmune mice and after the antigen challenge in allergic inflammatory diseases. Our results suggest a different action of B7-H4 in T cell-mediated inflammatory responses and the possible involvement of soluble B7-H4 in inflammatory immune responses."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.08.144"xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/author | "Hirose S."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/author | "Kamimura Y."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/author | "Kobori H."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/author | "Hashiguchi M."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/author | "Piao J."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/pages | "349-353"xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/title | "Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses."xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://purl.uniprot.org/core/volume | "389"xsd:string |
| http://purl.uniprot.org/citations/19723502 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19723502 |
| http://purl.uniprot.org/citations/19723502 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19723502 |
| http://purl.uniprot.org/uniprot/#_Q7TSP5-mappedCitation-19723502 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19723502 |
| http://purl.uniprot.org/uniprot/Q7TSP5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19723502 |