| http://purl.uniprot.org/citations/19724910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19724910 | http://www.w3.org/2000/01/rdf-schema#comment | "The negative signal provided by interactions of programmed death-1 (PD-1) and its ligands, B7-H1 and B7-DC, has been suggested to play an important role in tumor evasion from host immunity. Pancreas cancer patients with B7-H1 expression have a poor prognosis. B7-H1 blocking has been shown to inhibit the development of a subcutaneous tumor from a pancreas cancer cell line. In this study, we investigated the effects of B7-DC as well as B7-H1 blockade in vivo in a murine pancreatic cancer model. Pancreatic cancer cells (Panc02) were inoculated in the pancreas of C57BL/6 mice. Five weeks later, tumor sizes were measured and the mice bearing appropriate size of tumors received the following treatments. Blocking antibodies against B7-H1 or B7-DC (200 microg) were administered 3 times/week for 3 weeks. Cells infiltrating the tumors were characterized by immunohistochemistry. Effects of antibodies on cytokine and FoxP3 expression were examined by quantitative RT-PCR. In vitro cultured Panc02 cells expressed B7-H1 upon IFN-gamma stimulation. However, expression of B7-H1 and B7-DC was found mainly on CD45-positive infiltrating cells and rarely on cancer cells in vivo. Treatment with both antibodies significantly decreased tumor growth in vivo. B7-DC blockade decreased the levels of IL-10 and FoxP3, suggesting that regulatory systems are mainly inhibited at the tumor site. B7-H1 blockade increased the levels of IFN-gamma and FoxP3. Collectively, blocking of B7-H1 or B7-DC efficiently induced regression of pre-established pancreatic cancers by up-regulating IFN-gamma production and down-regulating IL-10 production at the tumor site."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijo_00000387"xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Miura S."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Okada Y."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Watanabe C."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Nagao S."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Kawaguchi A."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Kurihara C."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Komoto S."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Okudaira K."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Hokari R."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/author | "Tsuzuki Y."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/pages | "741-749"xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/title | "Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model."xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/19724910 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19724910 |
| http://purl.uniprot.org/citations/19724910 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19724910 |
| http://purl.uniprot.org/uniprot/#_Q3U304-mappedCitation-19724910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19724910 |
| http://purl.uniprot.org/uniprot/#_Q7TQB5-mappedCitation-19724910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19724910 |
| http://purl.uniprot.org/uniprot/#_Q3U472-mappedCitation-19724910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19724910 |