| http://purl.uniprot.org/citations/19726632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19726632 | http://www.w3.org/2000/01/rdf-schema#comment | "Stabilin-1 is specifically expressed in alternatively activated macrophages. These macrophages participate in anti-inflammatory and healing processes, and display a high phagocytic capacity. In this study, we provide evidence that stabilin-1 is a membrane receptor that performs a crucial function in the clearance of cell corpses. Stabilin-1 is expressed on the cell surface of alternatively activated macrophages and is recruited to the sites of recognition and engulfment of apoptotic bodies, as well as to early phagosomes. Blocking stabilin-1 in macrophages results in defective engulfment of aged red blood cells. Ectopic expression of stabilin-1 induces the binding and engulfment of aged cells in mouse fibroblast L cells. The binding and phagocytosis are dependent on phosphatidylserine (PS), which is well known as an engulfing ligand. Furthermore, using PS-coated beads, we demonstrate that PS directly interacts with stabilin-1 and is sufficient for stabilin-1-mediated phagocytosis. EGF-like domain repeat in stabilin-1 is responsible for PS recognition and binding. Thus, our results demonstrate that stabilin-1, found on alternatively activated macrophages, is a phagocytic receptor mediating the clearance of apoptotic cells in a PS-dependent manner. Therefore, this protein might play an important role in the maintenance of tissue homeostasis and prevention of autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.049569"xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Jung M.Y."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Kim I.S."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Kang K.B."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Kzhyshkowska J."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Gratchev A."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/author | "Riabov V."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/pages | "3365-3373"xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/title | "Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages."xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/19726632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19726632 |
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