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http://purl.uniprot.org/citations/19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19727691http://www.w3.org/2000/01/rdf-schema#comment"Protein tyrosine phosphatases (PTPs) are key regulators of different processes during development of the central nervous system. However, expression patterns and potential roles of PTPs in the developing superior colliculus remain poorly investigated. In this study, a degenerate primer-based reverse transcription-polymerase chain reaction (RT-PCR) approach was used to isolate seven different intracellular PTPs and nine different receptor-type PTPs (RPTPs) from embryonic E15 mouse superior colliculus. Subsequently, the expression patterns of 11 PTPs (TC-PTP, PTP1C, PTP1D, PTP-MEG2, PTP-PEST, RPTPJ, RPTPε, RPTPRR, RPTPσ, RPTPκ and RPTPγ) were further analyzed in detail in superior colliculus from embryonic E13 to postnatal P20 stages by quantitative real-time RT-PCR, Western blotting and immunohistochemistry. Each of the 11 PTPs exhibits distinct spatiotemporal regulation of mRNAs and proteins in the developing superior colliculus suggesting their versatile roles in genesis of neuronal and glial cells and retinocollicular topographic mapping. At E13, additional double-immunohistochemical analysis revealed the expression of PTPs in collicular nestin-positive neural progenitor cells and RC-2-immunoreactive radial glia cells, indicating the potential functional importance of PTPs in neurogenesis and gliogenesis."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.org/dc/terms/identifier"doi:10.1007/s00221-009-1963-6"xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/author"Ullrich A."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/author"Reinhard J."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/author"Knyazev P."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/author"Zaremba A."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/author"Faissner A."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/author"Horvat-Brocker A."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/author"Illes S."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/name"Exp Brain Res"xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/pages"279-297"xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/title"Protein tyrosine phosphatases expression during development of mouse superior colliculus."xsd:string
http://purl.uniprot.org/citations/19727691http://purl.uniprot.org/core/volume"199"xsd:string
http://purl.uniprot.org/citations/19727691http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19727691
http://purl.uniprot.org/citations/19727691http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19727691
http://purl.uniprot.org/uniprot/#_A0A1L1STP0-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691
http://purl.uniprot.org/uniprot/#_A0A286YDF6-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691
http://purl.uniprot.org/uniprot/#_A0A286YDQ1-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691
http://purl.uniprot.org/uniprot/#_A0A1D5RLZ1-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691
http://purl.uniprot.org/uniprot/#_E9Q7I7-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691
http://purl.uniprot.org/uniprot/#_A0A1B0GRH2-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691
http://purl.uniprot.org/uniprot/#_A0A1B0GRT6-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691
http://purl.uniprot.org/uniprot/#_A0A0R4J080-mappedCitation-19727691http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19727691