| http://purl.uniprot.org/citations/19729412 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19729412 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, associations of several common genetic variants with height have been reported in different populations. We attempted to identify further variants associated with adult height in a self-contained population (the Sorbs in Eastern Germany) as discovery set. We performed a genome wide association study (GWAS) (approximately 390,000 genetic polymorphisms, Affymetrix gene arrays) on adult height in 929 Sorbian individuals. Subsequently, the best SNPs (P < 0.001) were taken forward to a meta-analysis together with two independent cohorts [Diabetes Genetics Initiative, British 1958 Birth Cohort, (58BC, publicly available)]. Furthermore, we genotyped our best signal for replication in two additional German cohorts (Leipzig, n = 1044 and Berlin, n = 1728). In the primary Sorbian GWAS, we identified 5 loci with a P-value < 10(-5) and 455 SNPs with P-value < 0.001. In the meta-analysis on those 455 SNPs, only two variants in GPR133 (rs1569019 and rs1976930; in LD with each other) retained a P-value at or below 10(-6) and were associated with height in the three cohorts individually. Upon replication, the SNP rs1569019 showed significant effects on height in the Leipzig cohort (P = 0.004, beta = 1.166) and in 577 men of the Berlin cohort (P = 0.049, beta = 1.127) though not in women. The combined analysis of all five cohorts (n = 6,687) resulted in a P-value of 4.7 x 10(-8) (beta = 0.949). In conclusion, our GWAS suggests novel loci influencing height. In view of the robust replication in five different cohorts, we propose GPR133 to be a novel gene associated with adult height."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddp423"xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Dietrich K."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Groop L."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Hoffmann K."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Aust G."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Krohn K."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Rayner N.W."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Pfeiffer A."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Almgren P."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Spranger J."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Stumvoll M."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Tonjes A."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Kovacs P."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Bluher M."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Schleinitz D."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Bottcher Y."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Enigk B."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Richter O."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Rohm S."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Fischer-Rosinsky A."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/author | "Koriath M."xsd:string |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19729412 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |