| http://purl.uniprot.org/citations/19732720 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19732720 | http://www.w3.org/2000/01/rdf-schema#comment | "ErbB2, a metastasis-promoting oncoprotein, is overexpressed in approximately 25% of invasive/metastatic breast cancers, but in 50%-60% of noninvasive ductal carcinomas in situ (DCIS). It has been puzzling how a subset of ErbB2-overexpressing DCIS develops into invasive breast cancer (IBC). We found that co-overexpression of 14-3-3zeta in ErbB2-overexpressing DCIS conferred a higher risk of progression to IBC. ErbB2 and 14-3-3zeta overexpression, respectively, increased cell migration and decreased cell adhesion, two prerequisites of tumor cell invasion. 14-3-3zeta overexpression reduced cell adhesion by activating the TGF-beta/Smads pathway that led to ZFHX1B/SIP-1 upregulation, E-cadherin loss, and epithelial-mesenchymal transition. Importantly, patients whose breast tumors overexpressed both ErbB2 and 14-3-3zeta had higher rates of metastatic recurrence and death than those whose tumors overexpressed only one."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2009.08.010"xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Feng X."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Lu J."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Shi B."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Ling C."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Sahin A."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Chiao P.J."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Muller W.J."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Seewaldt V.L."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/author | "Treekitkarnmongkol W."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/pages | "195-207"xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/title | "14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition."xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/19732720 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19732720 |