| http://purl.uniprot.org/citations/19734146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19734146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19734146 | http://www.w3.org/2000/01/rdf-schema#comment | "We identified a novel GTPase, SLIP-GC, with expression limited to a few tissues, in particular germinal center B cells. It lacks homology to any known proteins, indicating that it may belong to a novel family of GTPases. SLIP-GC is expressed in germinal center B cells and in lymphomas derived from germinal center B cells such as large diffuse B cell lymphomas. In cell lines, SLIP-GC is expressed in lymphomas that express activation-induced deaminase (AID) and that likely undergo somatic hypermutation. SLIP-GC is a nuclear protein, and it localizes to replication factories. Reduction of SLIP-GC levels in the Burkitt lymphoma cell line Raji and in non-Hodgkin lymphoma cell lines resulted in an increase in DNA breaks and apoptosis that was AID-dependent, as simultaneous reduction of AID abrogated the deleterious effects of SLIP-GC reduction. These results strongly suggest that SLIP-GC is a replication-related protein in germinal center B cells whose reduction is toxic to cells through an AID-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.014506"xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.014506"xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Richter K."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Richter K."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Diaz M."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Diaz M."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Ray M."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Ray M."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Bolland S."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Bolland S."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Brar S.S."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Brar S.S."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Pisitkun P."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Pisitkun P."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Verkoczy L."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/author | "Verkoczy L."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/pages | "30652-30661"xsd:string |
| http://purl.uniprot.org/citations/19734146 | http://purl.uniprot.org/core/pages | "30652-30661"xsd:string |