| http://purl.uniprot.org/citations/19734230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19734230 | http://www.w3.org/2000/01/rdf-schema#comment | "In the thymus, the transcription factor ThPOK is essential for the development of the CD4 helper T cell lineage, whereas active repression of ThPOK is critical for the development of the CD8 cytotoxic T cell lineage. ThPOK gene silencing is thought to be irreversible in peripheral CD8 T cells. We noticed that ThPOK repression is readily abrogated upon in vitro TCR stimulation of peripheral CD8 T cells. This observation prompted us to investigate a role for ThPOK in the CD8 T cell response to an acute viral infection. We observed that a functional deficiency of ThPOK does not affect CD8 T cell differentiation into effector T cells and the long-term persistence of Ag-specific memory T cells. However, in the absence of functional ThPOK, clonal expansion is significantly less in both primary and secondary CD8 T cell responses. Long-lived, Ag-specific CD8 T cells with a functional deficiency in ThPOK fail to produce high amounts of IL-2 and also fail to express high levels of granzyme B upon rechallenge. Our data reveal an unexpected role for ThPOK in CD8 T cells in promoting expansion and boosting the response to antigenic challenge."xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0901428"xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/author | "Bevan M.J."xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/author | "Taniuchi I."xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/author | "Setoguchi R."xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/pages | "4467-4474"xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/title | "ThPOK derepression is required for robust CD8 T cell responses to viral infection."xsd:string |
| http://purl.uniprot.org/citations/19734230 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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