| http://purl.uniprot.org/citations/19734231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19734231 | http://www.w3.org/2000/01/rdf-schema#comment | "Suppressor of cytokine signaling (SOCS)-1 is a critical inhibitor of IFN-gamma signal transduction in vivo, but the precise biochemical mechanism of action of SOCS-1 is unclear. Studies in vitro have shown that SOCS-1 binds to Jaks and inhibits their catalytic activity, but recent studies indicate SOCS-1 may act in a similar manner to SOCS-3 by firstly interacting with cytokine receptors and then inhibiting Jak activity. Here, we have generated mice, termed Ifngr1(441F), in which a putative SOCS-1 binding site, tyrosine 441 (Y441), on the IFN-gamma receptor subunit 1 (IFNGR1) is mutated. We confirm that SOCS-1 binds to IFNGR1 in wild-type but not mutant cells. Mutation of Y441 results in impaired negative regulation of IFN-gamma signaling. IFN-gamma-induced STAT1 activation is prolonged in Ifngr1(441F) cells, but not to the extent seen in cells completely lacking SOCS-1, suggesting that SOCS-1 maintains activity to modulate IFN-gamma signaling via other mechanisms. Despite this, we show that hypersensitivity to IFN-gamma results in enhanced innate tumor protection in Ifngr1(441F) mice in vivo, and unregulated expression of an IFN-gamma-dependent chemokine, monokine-induced by IFN-gamma. Collectively, these data indicate that Y441 contributes to the regulation of signaling through IFNGR1 via the recruitment of SOCS-1 to the receptor."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0901010"xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Alexander W.S."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Willson T.A."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Uldrich A.P."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Goradia A."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Verhagen A.M."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Starr R."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Fuchsberger M."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/author | "Lau L.S."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/pages | "4537-4544"xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/title | "SOCS-1 binding to tyrosine 441 of IFN-gamma receptor subunit 1 contributes to the attenuation of IFN-gamma signaling in vivo."xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19734231 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19734231 |
| http://purl.uniprot.org/citations/19734231 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19734231 |
| http://purl.uniprot.org/uniprot/#_P15260-mappedCitation-19734231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19734231 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-19734231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19734231 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-19734231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19734231 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3Y2-mappedCitation-19734231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19734231 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3R7-mappedCitation-19734231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19734231 |
| http://purl.uniprot.org/uniprot/#_A0A2R8Y4U4-mappedCitation-19734231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19734231 |