| http://purl.uniprot.org/citations/19735075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19735075 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF, lymphotoxin (LT)-alpha, LT-beta and LIGHT are members of a larger superfamily of TNF-related cytokines that can cross-utilize several receptors. Although LIGHT has been implicated in thymic development and function, the role of TNF and LT remains incompletely defined. To address this, we created a model of modest homeostatic overexpression of TNF/LT cytokines using the genomic human TNF/LT locus as a low copy number Tg. Strikingly, expression of Tg TNF/LT gene products led to profound early thymic atrophy characterized by decreased numbers of thymocytes and cortical thymic epithelial cells, partial block of thymocyte proliferation at double negative (DN) 1 stage, increased apoptosis of DN2 thymocytes and severe decline of T-cell numbers in the periphery. Results of backcrossing to TNFR1-, LTbetaR- or TNF/LT-deficient backgrounds and of reciprocal bone marrow transfers implicated both LT-alpha/LT-beta to LTbetaR and TNF/LT-alpha to TNFR1 signaling in accelerated thymus degeneration. We hypothesize that chronic infections can promote thymic atrophy by upregulating LT and TNF production."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200839191"xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Feigenbaum L."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Nedospasov S.A."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Kuprash D.V."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Grivennikov S.I."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Shakhov A.N."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Tumanov A.V."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Shebzukhov Y.V."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Kuchmiy A.A."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Kruglov A.A."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Liepinsh D.J."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Drutskaya M.S."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/author | "Galimov A.R."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/pages | "2906-2915"xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/title | "Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus."xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/19735075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19735075 |
| http://purl.uniprot.org/citations/19735075 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19735075 |
| http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-19735075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19735075 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J6H2-mappedCitation-19735075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19735075 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7Z3-mappedCitation-19735075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19735075 |