| http://purl.uniprot.org/citations/19735483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19735483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19735483 | http://www.w3.org/2000/01/rdf-schema#comment | "The intestine plays an essential role in organism-wide regulatory networks in both vertebrates and invertebrates. In Caenorhabditis elegans, class 1 flr genes (flr-1, flr-3 and flr-4) act in the intestine and control growth rates and defecation cycle periods, while class 2 flr genes (flr-2, flr-5, flr-6 and flr-7) are characterized by mutations that suppress the slow growth of class 1 flr mutants. This study revealed that flr-2 gene controls antibacterial defense and intestinal color, confirming that flr-2 regulates intestinal functions. flr-2 encoded the only glycoprotein hormone alpha subunit in C. elegans and was expressed in certain neurons. Furthermore, FLR-2 bound to another secretory protein GHI-1, which belongs to a family of lipid- and lipopolysaccharide-binding proteins. A ghi-1 deletion mutation partially suppressed the short defecation cycle periods of class 1 flr mutants, and this effect was enhanced by flr-2 mutations. Thus, FLR-2 acts as a signaling molecule for the neural control of intestinal functions, which is achieved in a functional network involving class 1 and class 2 flr genes as well as ghi-1. These results are informative to studies of glycoprotein hormone signaling in higher animals."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2009.01341.x"xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2009.01341.x"xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Katsura I."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Katsura I."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Gengyo-Ando K."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Ishihara T."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Ishihara T."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Kimura K.D."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Kimura K.D."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Mohri-Shiomi A."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Mohri-Shiomi A."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Oishi A."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Oishi A."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/author | "Gengyo-Ando A."xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/pages | "1141-1154"xsd:string |
| http://purl.uniprot.org/citations/19735483 | http://purl.uniprot.org/core/pages | "1141-1154"xsd:string |