| http://purl.uniprot.org/citations/19737917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19737917 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoblasts and chondrocytes arise from common osteo-chondroprogenitor cells. We show here that inactivation of ERK1 and ERK2 in osteo-chondroprogenitor cells causes a block in osteoblast differentiation and leads to ectopic chondrogenic differentiation in the bone-forming region in the perichondrium. Furthermore, increased mitogen-activated protein kinase signaling in mesenchymal cells enhances osteoblast differentiation and inhibits chondrocyte differentiation. These observations indicate that extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in the lineage specification of mesenchymal cells. The inactivation of ERK1 and ERK2 resulted in reduced beta-catenin expression, suggesting a role for canonical Wnt signaling in ERK1 and ERK2 regulation of skeletal lineage specification. Furthermore, inactivation of ERK1 and ERK2 significantly reduced RANKL expression, accounting for a delay in osteoclast formation. Thus, our results indicate that ERK1 and ERK2 not only play essential roles in the lineage specification of osteo-chondroprogenitor cells but also support osteoclast formation in vivo."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01549-08"xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/author | "Murakami S."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/author | "Matsushita T."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/author | "Chan Y.Y."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/author | "Landreth G.E."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/author | "Balmes G."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/author | "Kawanami A."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/pages | "5843-5857"xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/title | "Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis."xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19737917 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19737917 |
| http://purl.uniprot.org/citations/19737917 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19737917 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-19737917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19737917 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-19737917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19737917 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWC4-mappedCitation-19737917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19737917 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG89-mappedCitation-19737917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19737917 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-19737917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19737917 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-19737917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19737917 |
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