| http://purl.uniprot.org/citations/19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19741596 | http://www.w3.org/2000/01/rdf-schema#comment | "A PRoliferation-Inducing Ligand (APRIL) is a secreted cytokine member of the tumor necrosis factor family. It is a B-cell survival factor that also induces class switch recombination (CSR) toward immunoglobulin A (IgA), independent of T cells. It is therefore an important contributor to the maintenance of the mucosal immunological barrier, which has been linked to a putative extrafollicular inductive phase of the IgA response in lamina propria. By immunohistochemistry (IHC) and quantitative real-time PCR (qRT-PCR) on microdissected tissue from normal human gut, we observed APRIL expression, together with TACI (transmembrane activator and CAML interactor) and BCMA (B-cell maturation antigen), in gut-associated lymphoid tissue (GALT), lamina propria, and in the epithelium of stomach, small and large intestine, and rectum. However, no activation-induced cytidine deaminase (AID) expression (an absolute requirement for class switching) was detected in lamina propria by IHC or qRT-PCR. APRIL and its receptors were only observed alongside AID in GALT, showing that GALT contains the apparatus to support both T-independent and T-dependent routes to IgA CSR."xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.org/dc/terms/identifier | "doi:10.1038/mi.2009.106"xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/author | "Patel P."xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/author | "Spencer J."xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/author | "Barone F."xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/author | "Sanderson J.D."xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/name | "Mucosal Immunol"xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/pages | "495-503"xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/title | "Gut-associated lymphoid tissue contains the molecular machinery to support T-cell-dependent and T-cell-independent class switch recombination."xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/19741596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19741596 |
| http://purl.uniprot.org/citations/19741596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19741596 |
| http://purl.uniprot.org/uniprot/#_A0A0U5EM56-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_A0A141AWZ3-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_A3QRX5-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_B3KR02-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_A5Y848-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_A7KBT3-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_A7KBT4-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_A7KBT6-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_Q53F36-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_O75888-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |
| http://purl.uniprot.org/uniprot/#_Q02223-mappedCitation-19741596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741596 |