| http://purl.uniprot.org/citations/19741715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19741715 | http://www.w3.org/2000/01/rdf-schema#comment | "Notwithstanding the well-established association of HLA-DRB1 shared epitope alleles, interest remains in identifying additional major histocompatibility complex (MHC) region variants associated with rheumatoid arthritis (RA). We used a panel of 1201 haplotype-tagging single nucleotide polymorphisms (SNPs) designed for African Americans to find genetic variants associated with RA in a 3.8-Mb region encompassing the MHC. Conditioning on seven covariates, including HLA-DRB1 risk alleles and population structure, we identified an SNP in HLA-DOA (rs9276977) significantly associated with RA; minor allele frequency (MAF) 0.27 in cases versus 0.21 in controls, odds ratio (+/-95% confidence interval)=2.86 (1.61, 5.31). Genotyping of rs9276977 in an independent sample of African-American RA patients and controls did not replicate the association (MAF 0.28 in cases versus 0.27 in controls). This study points to the potential association of a SNP in the HLA-DOA gene with RA in African Americans, but also underscores the importance of replication of findings in larger patient cohorts."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2009.69"xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Kelley J.M."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Smith E.A."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Howard G."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Yi N."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Reynolds R.J."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Hughes L.B."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Alarcon G.S."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Bridges S.L. Jr."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Moreland L.W."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Callahan L.F."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Conn D.L."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Jonas B.L."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/author | "Brasington R.D. Jr."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/pages | "94-97"xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/title | "Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population."xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/19741715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19741715 |
| http://purl.uniprot.org/citations/19741715 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19741715 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19741715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741715 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19741715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19741715 |