| http://purl.uniprot.org/citations/19747914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19747914 | http://www.w3.org/2000/01/rdf-schema#comment | "We reported previously that NSC606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (AML) cells through proteolytic activation of protein kinase C delta (DeltaPKC-delta). By subcellular proteome analysis, heterogeneous nuclear ribonucleoprotein K (hnRNP K) was identified as being significantly down-regulated in NSC606985-treated leukemic NB4 cells. HnRNP K, a docking protein for DNA, RNA, and transcriptional or translational molecules, is implicated in a host of processes involving the regulation of gene expression. However, the molecular mechanisms of hnRNP K reduction and its roles during apoptosis are still not understood. In the present study, we found that, following the appearance of the DeltaPKC-delta, hnRNP K protein was significantly down-regulated in NSC606985, doxorubicin, arsenic trioxide and ultraviolet-induced apoptosis. We further provided evidence that DeltaPKC-delta mediated the down-regulation of hnRNP K protein during apoptosis: PKC-delta inhibitor could rescue the reduction of hnRNP K; hnRNP K failed to be decreased in PKC-delta-deficient apoptotic KG1a cells; conditional induction of DeltaPKC-delta in U937T cells directly down-regulated hnRNP K protein. Moreover, the proteasome inhibitor also inhibited the down-regulation of hnRNP K protein by apoptosis inducer and the conditional expression of DeltaPKC-delta. More intriguingly, the suppression of hnRNP K with siRNA transfection significantly induced apoptosis. To our knowledge, this is the first demonstration that proteolytically activated PKC-delta down-regulates hnRNP K protein in a proteasome-dependent manner, which plays an important role in apoptosis induction."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2009.09.005"xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/author | "Chen G.Q."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/author | "Zhao M."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/author | "Liu C.X."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/author | "Wu Y.L."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/author | "Wang L.S."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/author | "Gao F.H."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/pages | "3250-3258"xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/title | "Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction."xsd:string |
| http://purl.uniprot.org/citations/19747914 | http://purl.uniprot.org/core/volume | "315"xsd:string |
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