| http://purl.uniprot.org/citations/19749740 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19749740 | http://www.w3.org/2000/01/rdf-schema#comment | "Mucoepidermoid carcinoma is the most common primary malignancy of the salivary gland. We and others showed that CRTC1-MAML2 gene fusion was associated with favorable clinicopathological tumor features. Recently, a novel gene fusion, CRTC3-MAML2, was reported as a rare gene alteration in a case of mucoepidermoid carcinoma. However, its frequency and clinicopathological significance remains unclear. In all, 101 cases of mucoepidermoid carcinoma and 89 cases of non-mucoepidermoid carcinoma of the salivary gland were analyzed, and RNA was extracted from formalin-fixed, paraffin-embedded specimens. In the CRTC family, there have been three genes, CRTC1, CRTC2, and CRTC3. We developed reverse transcription-polymerase chain reaction (RT-PCR) assays for CRTC1-MAML2, CRTC2-MAML2, and CRTC3-MAML2 fusions. Clinicopathological data of the patients were obtained from their clinical records. Of 101 cases of mucoepidermoid carcinoma, 34 (34%) and 6 (6%) were positive for CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts. However, in the 89 cases of non-mucoepidermoid carcinoma, neither transcript was noted. In the former cases, CRTC1-MAML2 and CRTC3-MAML2 fusions were mutually exclusive. The other fusion, CRTC2-MAML2, was not detected. We confirmed that the clinicopathological features of CRTC1-MAML2-positive mucoepidermoid carcinomas indicated an indolent course. CRTC3-MAML2-positive mucoepidermoid carcinomas also had clinicopathologically favorable features; all cases showed a less advanced clinical stage, negative nodal metastasis, no high-grade tumor histology, and no recurrence or tumor-related death after surgical resection of the tumor. It is interesting to note that patients with CRTC3-MAML2-positive tumors (mean 36 years of age) were significantly younger that those with the CRTC1-MAML2 fusion (55 years) and those with fusion-negative tumors (58 years). In conclusion, CRTC3-MAML2 fusion, which is mutually exclusive with CRTC1-MAML2 fusion and specific to mucoepidermoid carcinoma, may be detected more frequently than previously expected. Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.org/dc/terms/identifier | "doi:10.1038/modpathol.2009.126"xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Inagaki H."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Hasegawa Y."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Nakayama T."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Okabe M."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Sakuma H."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Shimozato K."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Miyabe S."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Nagatsuka H."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/author | "Ijichi K."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/name | "Mod Pathol"xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/pages | "1575-1581"xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/title | "Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma."xsd:string |
| http://purl.uniprot.org/citations/19749740 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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