| http://purl.uniprot.org/citations/19752753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19752753 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of tumors are still resistant to the antiproliferative activity of human interferon (IFN)-alpha. The Janus kinases/Signal Transducers and Activators of Transcription (JAK-STAT) pathway plays an important role in initial IFN signaling. To enhance the antiproliferative activity of IFN-alpha, it is important to elucidate which factors in the JAK-STAT pathway play a key role in eliciting this activity. In human ovarian adenocarcinoma OVCAR3 cells sensitive to both IFN-alpha and IFN-gamma, only IFN regulatory factor 9 (IRF9)-RNA interference (RNAi) completely inhibited the antiproliferative activity of IFN-alpha among the intracellular JAK-STAT pathway factors. Conversely, Stat1-RNAi did not inhibit the antiproliferative activity of IFN-alpha, whereas it partially inhibited that of IFN-gamma. As a cell death pathway, it is reported that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis through TRAIL-receptor (R) 1 and TRAIL-R2. In IFN-alpha-treated OVCAR3 cells, IRF9-RNAi inhibited transcription of TRAIL whereas Stat1-RNAi did not, suggesting that the transcription of TRAIL induced by IFN-alpha predominantly required IRF9. Furthermore, IFN-stimulated response element-like motifs of TRAIL bound to IFN-stimulated gene factor 3 (ISGF3) complex after IFN-alpha treatment. Subsequently, TRAIL-R2-RNAi inhibited both antiproliferative activities of IFN-alpha and TRAIL, suggesting that TRAIL-R2 mediated both IFN-alpha and TRAIL signals to elicit their antiproliferative activities. Finally, IRF9 overexpression facilitated IFN-alpha-induced apoptosis in T98G (human glioblastoma multiforme) cells, which were resistant to IFN-alpha. Thus, this study suggests that IRF9 is the key factor for eliciting the antiproliferative activity of IFN-alpha and TRAIL may be one of the potential mediators."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.org/dc/terms/identifier | "doi:10.1097/cji.0b013e3181ad4092"xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/author | "Zhao T."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/author | "Morrow A."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/author | "Schmeisser H."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/author | "Zoon K.C."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/author | "Mejido J."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/author | "Tsuno T."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/name | "J Immunother"xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/pages | "803-816"xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/title | "IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha."xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19752753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19752753 |
| http://purl.uniprot.org/citations/19752753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19752753 |
| http://purl.uniprot.org/uniprot/#_B4DI86-mappedCitation-19752753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752753 |
| http://purl.uniprot.org/uniprot/#_Q00978-mappedCitation-19752753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752753 |
| http://purl.uniprot.org/uniprot/Q00978 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19752753 |
| http://purl.uniprot.org/uniprot/B4DI86 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19752753 |