| http://purl.uniprot.org/citations/19752773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19752773 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesTo define the role of protein kinase C delta (PKC delta) in acinar cell responses to the hormone cholecystokinin-8 (CCK) using isoform-specific inhibitors and a previously unreported genetic deletion model.MethodsPancreatic acinar cells were isolated from (1) rat, and pretreated with a PKC delta-specific inhibitor or (2) PKC delta-deficient and wild type mice. Isolated cells were stimulated with CCK (0.001-100 nmol/L) and cell responses were measured.ResultsThe PKC delta inhibitor did not affect stimulated amylase secretion from rat pancreatic acinar cells. Cholecystokinin-8 stimulation induced a typical biphasic dose-response curve for amylase secretion in acinar cells isolated from both PKC delta(-/-) and wild type mice, with maximal stimulation at 10-pmol/L CCK. Cholecystokinin-8 (100 nmol/L) induced zymogen and nuclear factor kappaB activation in both PKC delta(-/-) and wild type mice, although it was up to 50% less in PKC delta(-/-).ConclusionsIn contrast to previous studies, this study has used specific and complementary approaches to examine PKC delta-mediated acinar cell responses. We could not confirm that it mediates amylase release but corroborated its role in the early stages of acute pancreatitis."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.org/dc/terms/identifier | "doi:10.1097/mpa.0b013e3181b8476a"xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Gorelick F.S."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Reeve J.R. Jr."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Pandol S.J."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Lugea A."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Thrower E.C."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Kolodecik T.R."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/author | "Cheriyan S."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/name | "Pancreas"xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/pages | "930-935"xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/title | "Protein kinase C delta-mediated processes in cholecystokinin-8-stimulated pancreatic acini."xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/19752773 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19752773 |
| http://purl.uniprot.org/citations/19752773 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19752773 |
| http://purl.uniprot.org/uniprot/#_A0A140UHX0-mappedCitation-19752773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752773 |
| http://purl.uniprot.org/uniprot/#_A6KG32-mappedCitation-19752773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752773 |
| http://purl.uniprot.org/uniprot/#_F1DGF6-mappedCitation-19752773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752773 |
| http://purl.uniprot.org/uniprot/#_P28867-mappedCitation-19752773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752773 |
| http://purl.uniprot.org/uniprot/#_Q1MX42-mappedCitation-19752773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752773 |
| http://purl.uniprot.org/uniprot/#_Q1MX43-mappedCitation-19752773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19752773 |