| http://purl.uniprot.org/citations/19758175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19758175 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor nuclear factor-kappaB (NF-kappaB) is a ubiquitously expressed protein family that is considered crucial in autoimmunity. We describe NF-kappaB p50 and p65, and the inhibitor I-kappaB alpha in the inflammatory exudates characteristic for the different idiopathic inflammatory myopathies (IIM), that is, endomysial CD8(+) cytotoxic T cells invading non-necrotic fibers in polymyositis (PM) and sporadic inclusion body myositis (sIBM), and the perimysial/perivascular CD20(+) B cells and CD4(+) T cells in dermatomyositis (DM). We also analyzed other inflammatory cells in the vicinity of active inflammation sites. Strikingly, actively invading CD4(+) cells in PM and sIBM contained both p65 and p50, whereas I-kappaB alpha was absent. This could point to a high activation state in which these cells are capable of expressing a variety of inflammatory mediators, contributing to the degradation of non-necrotic fibers. Secondly, CD68(+) macrophages in the infiltrates in all three IIM subtypes showed strong nuclear p50 and I-kappaB alpha staining. This may point to a role for p50 in counteracting inflammation, a reaction that could be enhanced by an upregulation of I-kappaB alpha as we observed with immunofluorescence. These results shed further light on the immunopathology of PM, sIBM and DM. CD4(+) and CD68(+) mononuclear cells may play a more prominent role than previously assumed."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1749-6632.2009.04874.x"xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/author | "Weis J."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/author | "De Paepe B."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/author | "De Bleecker J.L."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/author | "Creus K.K."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/author | "Vervaet V."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/author | "Werbrouck B.F."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/pages | "370-377"xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/title | "Distribution of the NF-kappaB complex in the inflammatory exudates characterizing the idiopathic inflammatory myopathies."xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://purl.uniprot.org/core/volume | "1173"xsd:string |
| http://purl.uniprot.org/citations/19758175 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19758175 |
| http://purl.uniprot.org/citations/19758175 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19758175 |
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| http://purl.uniprot.org/uniprot/#_L0R6N5-mappedCitation-19758175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19758175 |
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| http://purl.uniprot.org/uniprot/#_Q2TAM5-mappedCitation-19758175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19758175 |
| http://purl.uniprot.org/uniprot/#_P78359-mappedCitation-19758175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19758175 |
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| http://purl.uniprot.org/uniprot/#_P19838-mappedCitation-19758175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19758175 |