| http://purl.uniprot.org/citations/19758196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19758196 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional regulation of the major histocompatibility complex class (MHC) Ib gene HLA-G differs from the classical MHC class I genes. The cis-acting regulatory elements typical for classical MHC class I promoters are divergent in the promoter of HLA-G, rendering this gene unresponsive to NF-kappaB, IRF-1, and class II transactivator (CIITA)-mediated activation pathways. However, as we have previously shown, transactivation of HLA-G is regulated by CREB-1. Because CREB-1 is ubiquitously expressed, this observation does not explain the tissue-restricted expression of HLA-G in extravillous cytotrophoblasts. Using HLA-G-expressing JEG-3 cells and HLA-G-deficient JAR trophoblast-derived choriocarcinoma cells as a model, we have investigated the contribution of DNA methylation and histone acetylation in the transcriptional activation of HLA-G. Despite similar levels of DNA methylation both in JEG3 and JAR cells, we found the levels of histone acetylation in HLA-G promoter chromatin to be significantly enhanced in JEG3 cells coinciding with HLA-G expression."xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1749-6632.2009.04660.x"xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/author | "van den Elsen P.J."xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/author | "Holling T.M."xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/author | "van Eggermond M.C."xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/author | "Bergevoet M.W."xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/author | "Wierda R.J."xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/pages | "538-544"xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/title | "Genetic and epigenetic control of the major histocompatibility complex class Ib gene HLA-G in trophoblast cell lines."xsd:string |
| http://purl.uniprot.org/citations/19758196 | http://purl.uniprot.org/core/volume | "1173"xsd:string |
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