| http://purl.uniprot.org/citations/19759182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19759182 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcytosis via caveolae is critical for maintaining vascular homeostasis by regulating the tissue delivery of macromolecules, hormones, and lipids. In the present study, we test the hypothesis that interactions between F-actin cross-linking protein filamin A and caveolin-1 facilitate the internalization and trafficking of caveolae. Small interfering RNA-mediated knockdown of filamin A, but not filamin B, reduced the uptake and transcytosis of albumin by approximately 35 and 60%, respectively, without altering the actin cytoskeletal structure or cell-cell adherens junctions. Mobility of both intracellular caveolin-1-green fluorescent protein (GFP)-labeled vesicles measured by fluorescence recovery after photobleaching and membrane-associated vesicles measured by total internal reflection-fluorescence microscopy was decreased in cells with reduced filamin A expression. In addition, in melanoma cells that lack filamin A (M2 cells), the majority of caveolin-1-GFP was localized on the plasma membrane, whereas in cells in which filamin A expression was reconstituted (A7 cells and M2 cells transfected with filamin A-RFP), caveolin-1-GFP was concentrated in intracellular vesicles. Filamin A association with caveolin-1 in endothelial cells was confirmed by cofractionation of these proteins in density gradients, as well as by coimmunoprecipitation. Moreover, this interaction was enhanced by Src activation, associated with increased caveolin-1 phosphorylation, and blocked by Src inhibition. Taken together, these data suggest that filamin A association with caveolin-1 promotes caveolae-mediated transport by regulating vesicle internalization, clustering, and trafficking."xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e08-10-0997"xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/author | "Minshall R.D."xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/author | "Place A.T."xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/author | "Shinin V."xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/author | "Castellon M."xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/author | "Sverdlov M."xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/pages | "4531-4540"xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/title | "Filamin A regulates caveolae internalization and trafficking in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/19759182 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19759182 |
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