| http://purl.uniprot.org/citations/19761839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19761839 | http://www.w3.org/2000/01/rdf-schema#comment | "Purported genetic associations found in population studies require validation for confirmation. We previously reported rubella vaccine-induced immune responses and HLA associations in 346 adolescents, age 12-18 years (1st cohort), following two doses of a rubella-containing vaccine. We sought to replicate the associations discovered in that work by verifying these associations in a new cohort of 396 subjects, age 11-19 years (2nd cohort), all having had two doses of a rubella-containing vaccine. We found that B*2705 (median 1st cohort 20.9 IU/ml, p=0.028; 2nd cohort 20.5 IU/ml, p=0.001) and DPA1*0201 (median 1st cohort 32.5 IU/ml, p=0.048; 2nd cohort 25.8 IU/ml, p=0.025) alleles were consistently associated with lower rubella-induced antibodies. Further, DPB1*0401 (median 1st cohort 43.5 IU/ml, p=0.021; 2nd cohort 36.2 IU/ml, p=0.002) alleles were associated with higher antibody levels in both populations. The association of DRB1*04-DQB1*03-DPB1*03 (mean 1st cohort 25.2 IU/ml, p=0.011; 2nd cohort 21.4 IU/ml, p=0.032) and DRB1*15/16-DQB1*06-DPB1*03 (1st cohort 16.3 IU/ml, p=0.043; 2nd cohort 19.1 IU/ml, p=0.023) haplotypes with lower rubella-specific antibodies was observed in both studies. This study provides confirmatory evidence for an association between specific class I and II HLA markers and haplotypes with rubella vaccine-induced humoral responses and lends further weight to their influence on rubella immune responses."xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.vaccine.2009.08.109"xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/author | "Jacobson R.M."xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/author | "Ovsyannikova I.G."xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/author | "Poland G.A."xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/author | "Vierkant R.A."xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/author | "O'Byrne M.M."xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/name | "Vaccine"xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/pages | "6926-6931"xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/title | "Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations."xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/19761839 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19761839 |
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