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http://purl.uniprot.org/citations/19763017http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19763017http://www.w3.org/2000/01/rdf-schema#comment"

Aim

Data on the skeletal muscle characteristics of patients and animals with lifestyle-related diseases are limited. We investigated mRNA expression levels and fiber profiles in the skeletal muscles of rats with obesity, diabetes, hypertension, and/or hyperlipidemia.

Methods

The mRNA expression levels of peroxisome proliferator-activated receptors (PPARalpha and PPARdelta/beta), PPARgamma coactivator-1alpha (PGC-1alpha), stearoyl-CoA desaturase-1 (SCD-1), carnitine palmi-toyl-transferase I (CPT I), medium-chain acyl-CoA dehydrogenase (MCAD), and mitochondrial transcriptional factor A (TFAM) in the soleus muscles were compared among 15-week-old control (WR), type 2 diabetic (GK), hypertensive (SHR), and hyperlipidemic (CP) rats. The fiber profiles in the soleus muscles of these rats were also determined.

Results

GK rats showed lower PPARdelta/beta, PGC-1alpha, and MCAD expression levels than WR rats. SHR rats showed higher PPARalpha and MCAD and lower PPARdelta/beta expression levels than WR rats. CP rats showed lower PPARdelta/beta and higher SCD-1 expression levels than WR rats. The muscles of WR, SHR, and CP rats had low-oxidative type I and high-oxidative type IIA and type IIC fibers, whereas the muscle of GK rats had only low-oxidative type I fibers.

Conclusions

The skeletal muscles of rats with lifestyle-related diseases have unique mRNA expres-sion patterns and fiber profiles depending on the type of disease. For example, the lower PGC-1alpha and MCAD mRNA expression levels in the soleus muscles of type 2 diabetic rats are associated with the presence of only low-oxidative type I fibers in the muscle."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.org/dc/terms/identifier"doi:10.5551/jat.1065"xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/author"Tsuda K."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/author"Ishihara A."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/author"Fujino H."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/author"Gu N."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/author"Takeda I."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/author"Nagatomo F."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/name"J Atheroscler Thromb"xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/pages"576-585"xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/title"Skeletal muscle characteristics of rats with obesity, diabetes, hypertension, and hyperlipidemia."xsd:string
http://purl.uniprot.org/citations/19763017http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/19763017http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19763017
http://purl.uniprot.org/citations/19763017http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19763017
http://purl.uniprot.org/uniprot/#_P37230-mappedCitation-19763017http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19763017
http://purl.uniprot.org/uniprot/P37230http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19763017