| http://purl.uniprot.org/citations/19763173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19763173 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor p53 has been implicated in multiple functions that play key roles in health and disease, including ribosome biogenesis, control of aging, and cell cycle regulation. A genetic screen for negative regulators of innate immunity in Caenorhabditis elegans led to the identification of a mutation in NOL-6, a nucleolar RNA-associated protein (NRAP), which is involved in ribosome biogenesis and conserved across eukaryotic organisms. Mutation or silencing of NOL-6 and other nucleolar proteins results in an enhanced resistance to bacterial infections. A full-genome microarray analysis on animals with altered immune function due to mutation in nol-6 shows increased transcriptional levels of genes regulated by a p53 homologue, CEP-1. Further studies indicate that the activation of innate immunity by inhibition of nucleolar proteins requires p53/CEP-1 and its transcriptional target SYM-1. Since nucleoli and p53/CEP-1 are conserved, our results reveal an ancient immune mechanism by which the nucleolus may regulate immune responses against bacterial pathogens."xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000657"xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/author | "Smith J."xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/author | "Shianna K.V."xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/author | "Aballay A."xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/author | "Goel A.K."xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/author | "Fuhrman L.E."xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/pages | "e1000657"xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/title | "Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1."xsd:string |
| http://purl.uniprot.org/citations/19763173 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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