| http://purl.uniprot.org/citations/19767568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19767568 | http://www.w3.org/2000/01/rdf-schema#comment | "The CD4 coreceptor is mandatory for the differentiation and function of conventional MHC class II-restricted T cells, but little is known about its contribution in regulatory T cells (Tregs). We thus investigated the Treg compartment in mice lacking CD4. CD3+CD8-FoxP3+ cells were readily detected in the periphery of CD4(-/-) mice, where their percentages were even increased as compared with wild-type animals. These cells had a classical CD25+CD152+GITR+ Treg phenotype, were enriched in memory-type Tregs, and displayed a diversified TCR repertoire. Functionally, CD4(-/-) Tregs were equally as suppressive as CD4(+/+) Tregs in vitro as well as in vivo. Hence, the CD4 coreceptor is dispensable for the generation and function of FoxP3+ Tregs. Furthermore, CD3+CD8-FoxP3+ Tregs were also found to develop in the absence of both CD4 and MHC-II molecules, demonstrating that the generation of Tregs can occur independently of MHC-II recognition."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0901678"xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Arnoult C."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Six A."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Seman M."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Le Corre S."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Drouot L."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Boyer O."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Adriouch S."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Dulauroy S."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Calbo S."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/author | "Blache C."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/pages | "4182-4186"xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/title | "Cutting edge: CD4-independent development of functional FoxP3+ regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19767568 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19767568 |
| http://purl.uniprot.org/citations/19767568 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19767568 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-19767568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19767568 |
| http://purl.uniprot.org/uniprot/#_P70443-mappedCitation-19767568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19767568 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-19767568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19767568 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-19767568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19767568 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-19767568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19767568 |