| http://purl.uniprot.org/citations/19767768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19767768 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor angiogenesis is of paramount importance in solid tumor development. Elevated serum levels of YKL-40, which is a secreted heparin-binding glycoprotein, have been associated with a worse prognosis from various advanced human cancers. Yet the role of YKL-40 activity in these cancers is still missing. In this study, we showed that ectopic expression of YKL-40 in MDA-MB-231 breast cancer cells and in HCT-116 colon cancer cells led to larger tumor formation with an extensive angiogenic phenotype than did control cancer cells in mice. Affinity-purified recombinant YKL-40 protein promoted vascular endothelial cell angiogenesis in vitro, the effects of which are similar to the activities observed using MDA-MB-231 and HCT-116 cell-conditioned medium after transfection with YKL-40. Furthermore, YKL-40 was found to induce coordination of membrane-bound receptor syndecan-1 and integrin alpha(v)beta(3) and to activate an intracellular signaling cascade, including focal adhesion kinase and mitogen-activated protein kinase extracellular signal-related kinase1/2 in endothelial cells. Moreover, blockade of YKL-40 using small-interfering RNA gene knockdown suppressed tumor angiogenesis in vitro and in vivo. Immunohistochemical analysis of human breast cancer showed a correlation between YKL-40 expression and blood vessel density. These findings provide novel insights into angiogenic activities and molecular mechanisms of YKL-40 in cancer development."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.292"xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Yan W."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Bentley B."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Petersen L."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Shao R."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Bigelow C."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Arenas R.B."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Cao Q.J."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/author | "Hamel K."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/pages | "4456-4468"xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/title | "YKL-40, a secreted glycoprotein, promotes tumor angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/19767768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19767768 |
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