| http://purl.uniprot.org/citations/19767769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19767769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19767769 | http://www.w3.org/2000/01/rdf-schema#comment | "Ecotropic viral integration site-1 (Evi-1) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). Aberrant expression of Evi-1 has been frequently found in myeloid leukemia, and is associated with a poor patient survival. Recently, we reported candidate target genes of Evi-1 shared in HSCs and leukemic cells using gene expression profiling analysis. In this study, we identified Pbx1, a proto-oncogene in hematopoietic malignancy, as a target gene of Evi-1. Overexpression of Evi-1 increased Pbx1 expression in hematopoietic stem/progenitor cells. An analysis of the Pbx1 promoter region revealed that Evi-1 upregulates Pbx1 transcription. Furthermore, reduction of Pbx1 levels through RNAi-mediated knockdown significantly inhibited Evi-1-induced transformation. In contrast, knockdown of Pbx1 did not impair bone marrow transformation by E2A/HLF or AML1/ETO, suggesting that Pbx1 is specifically required for the maintenance of bone marrow transformation mediated by Evi-1. These results indicate that Pbx1 is a target gene of Evi-1 involved in Evi-1-mediated leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.288"xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.288"xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Ichikawa M."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Ichikawa M."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Yoshimi A."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Yoshimi A."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Goyama S."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Goyama S."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Shimabe M."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Shimabe M."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Watanabe-Okochi N."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/author | "Watanabe-Okochi N."xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/pages | "4364-4374"xsd:string |
| http://purl.uniprot.org/citations/19767769 | http://purl.uniprot.org/core/pages | "4364-4374"xsd:string |