| http://purl.uniprot.org/citations/19773165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19773165 | http://www.w3.org/2000/01/rdf-schema#comment | "A crystal structure of 1 bound to a Cys25Ser mutant of cathepsin S helped to elucidate the binding mode of a previously disclosed series of pyrazole-based CatS inhibitors and facilitated the design of a new class of arylalkyne analogs. Optimization of the alkyne and tetrahydropyridine portions of the pharmacophore provided potent CatS inhibitors (IC50=40-300 nM), and an X-ray structure of 32 revealed that the arylalkyne moiety binds in the S1 pocket of the enzyme."xsd:string |
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| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Sun S."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Randal M."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Karlsson L."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Thurmond R.L."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Axe F.U."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Edwards J.P."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Ameriks M.K."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/author | "Bembenek S.D."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/name | "Bioorg Med Chem Lett"xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/pages | "6131-6134"xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/title | "Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements."xsd:string |
| http://purl.uniprot.org/citations/19773165 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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