| http://purl.uniprot.org/citations/19778961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19778961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19778961 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is triggered when organisms sense radical environmental changes, including nutritional starvation. During autophagy, cytoplasmic components, including organelles, are enclosed within autophagosomes and are degraded upon lysosome-vacuole fusion. In this study, we show that processing of GFP-tagged Atg8 can serve as a marker for autophagy in the fission yeast Schizosaccharomyces pombe. Using this marker, 13 Atg homologues were also found to be required for autophagy in fission yeast. In budding yeast, autophagy-deficient mutants are known to be sterile, whereas in fission yeast we found that up to 30 % of autophagy-defective cells with amino acid auxotrophy were able to recover sporulation when an excess of required amino acids was supplied. Furthermore, we found that approximately 15 % of the autophagy-defective cells were also able to sporulate when a prototrophic strain was subjected to nitrogen starvation, which suggested that fission yeast may store sufficient intracellular nitrogen to allow partial sporulation under nitrogen-limiting conditions, although the majority of the nitrogen source is supplied by autophagy. Monitoring of the sporulation process revealed that the process was blocked non-specifically at various stages in the atg1Delta and atg12Delta mutants, possibly due to a shortage of amino acids. Taking advantage of this partial sporulation ability of fission yeast, we sought evidence for the existence of a recycling system for nitrogen sources during starvation."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.org/dc/terms/identifier | "doi:10.1099/mic.0.034389-0"xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.org/dc/terms/identifier | "doi:10.1099/mic.0.034389-0"xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Tanaka N."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Tanaka N."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Takegawa K."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Takegawa K."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Giga-Hama Y."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Giga-Hama Y."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Hosomi A."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Hosomi A."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Kajiwara S."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Kajiwara S."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Mukaiyama H."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/author | "Mukaiyama H."xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/name | "Microbiology"xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/name | "Microbiology"xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/pages | "3816-3826"xsd:string |
| http://purl.uniprot.org/citations/19778961 | http://purl.uniprot.org/core/pages | "3816-3826"xsd:string |