| http://purl.uniprot.org/citations/19779139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19779139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19779139 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous past studies have suggested a critical role of the paracrine effect between tumor vascular endothelial growth factor (VEGF)-C and lymphatic FLT-4 in solid tumor-associated lymphangiogenesis. In contrast, the pathophysiological role of tumor cell-associated FLT-4 in tumor progression remains to be elucidated. Here, we investigated this role using a tumor implantation model. SAS cells, an oral squamous carcinoma cell line expressing both VEGF-C and FLT-4 but neither FLK-1/KDR nor VEGF-D were adopted for experiments. Stable transformants of dominant-negative (dn) SAS cells were established in which the cytoplasmic domain-deleted FLT-4 was exogenously overexpressed, which can lead to inactivation of endogenous FLT-4 through competitive antagonism and is associated with down-activation of endogenous FLT-4-related intracellular signals. In vitro and in vivo proliferation assays showed lower proliferative activity of dn-SAS cells. An immunohistochemical study revealed that the tumor lymphangiogenesis was significantly suppressed, and the level of human VEGF-C mRNA was significantly lower in dn-SAS cell-derived tumor tissues. Moreover, in vitro studies demonstrated that the significant suppression of VEGF-C and VEGF-A expression was evident in dn-SAS cells or wild-type SAS cells treated with either the FLT-4 kinase inhibitor MAZ51 or the inhibitor of FLT-4-related signals. These findings together suggested that the VEGF-C/FLT-4 autocrine loop in tumor cells was a potential enhancer system to promote cancer progression, and FLT-4 in tumor tissue might become an effective target for cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.081139"xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.081139"xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Suzuki H."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Matsuura M."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Matsuura M."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Ishibashi H."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Ishibashi H."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Shirasuna K."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Shirasuna K."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Sueishi K."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Sueishi K."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Yonemitsu Y."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Yonemitsu Y."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Onimaru M."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/author | "Onimaru M."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |
| http://purl.uniprot.org/citations/19779139 | http://purl.uniprot.org/core/name | "Am. J. Pathol."xsd:string |