| http://purl.uniprot.org/citations/19783672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19783672 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary mast cell progenitor (MCp) numbers increase dramatically in sensitized and aerosolized Ag-challenged mice. This increase depends on CD4(+) T cells, as no MCp increase occurs in the lungs of sensitized wild-type (WT) mice after mAb depletion of CD4(+) but not CD8(+) cells before aerosol Ag challenge. Neither the genetic absence of IL-4, IL-4Ralpha chain, STAT-6, IFN-gamma, or IL-12p40 nor mAb blockade of IFN-gamma, IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17A, IL-12p40, or IL-12p40Rbeta1 before Ag challenge in WT mice reduces the pulmonary MCp increase. However, sensitized and Ag-challenged IL-9-deficient mice and sensitized WT mice given mAb to IL-9 just before Ag challenge show significant reductions in elicited lung MCp/10(6) mononuclear cells of 47 and 66%, respectively. CD1d-deficient mice and WT mice receiving anti-CD1d before Ag challenge also show significant reductions of 65 and 59%, respectively, in elicited lung MCp/10(6) mononuclear cells, revealing an additional requirement for MCp recruitment. However, in Jalpha18-deficient mice, which lack only type 1 or invariant NKT cells, the increase in the numbers of lung MCp with Ag challenge was intact, indicating that their recruitment must be mediated by type 2 NKT cells. Furthermore, anti-CD1d treatment of IL-9-deficient mice or anti-IL-9 treatment of CD1d-deficient mice does not further reduce the significant partial impairment of MCp recruitment occurring with a single deficiency. These findings implicate type 2 NKT cells and IL-9 as central regulators that function in the same pathway mediating the Ag-induced increase in numbers of pulmonary MCp."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0901471"xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Finkelman F.D."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Alcaide P."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Austen K.F."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Humbles A."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Gurish M.F."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Hallgren J."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Burwell T."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/author | "Jones T.G."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/pages | "5251-5260"xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/title | "Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells."xsd:string |
| http://purl.uniprot.org/citations/19783672 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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