| http://purl.uniprot.org/citations/19783783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19783783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19783783 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have shown that the rate of aging can be modulated by diverse interventions. Dietary restriction is the most widely used intervention to promote longevity; however, the mechanisms underlying the effect of dietary restriction remain elusive. In a previous study, we identified two novel genes, nlp-7 and cup-4, required for normal longevity in Caenorhabditis elegans. nlp-7 is one of a set of neuropeptide-like protein genes; cup-4 encodes an ion-channel involved in endocytosis by coelomocytes. Here, we assess whether nlp-7 and cup-4 mediate longevity increases by dietary restriction. RNAi of nlp-7 or cup-4 significantly reduces the life span of the eat-2 mutant, a genetic model of dietary restriction, but has no effect on the life span of long-lived mutants resulting from reduced insulin/IGF-1 signaling or dysfunction of the mitochondrial electron transport chain. The life-span extension observed in wild-type N2 worms by dietary restriction using bacterial dilution is prevented significantly in nlp-7 and cup-4 mutants. RNAi knockdown of genes encoding candidate receptors of NLP-7 and genes involved in endocytosis by coelomocytes also specifically shorten the life span of the eat-2 mutant. We conclude that two novel pathways, NLP-7 signaling and endocytosis by coelomocytes, are required for life extension under dietary restriction in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.09-142984"xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.09-142984"xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/author | "Johnson T.E."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/author | "Johnson T.E."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/author | "Park S.K."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/author | "Park S.K."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/author | "Link C.D."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/author | "Link C.D."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/name | "FASEB J."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/pages | "383-392"xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/pages | "383-392"xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/title | "Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/title | "Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/19783783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19783783 |
| http://purl.uniprot.org/citations/19783783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19783783 |
| http://purl.uniprot.org/citations/19783783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19783783 |
| http://purl.uniprot.org/citations/19783783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19783783 |