| http://purl.uniprot.org/citations/19787194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19787194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19787194 | http://www.w3.org/2000/01/rdf-schema#comment | "Isaac's syndrome is a movement disorder characterized by hyperexcitability of peripheral motor nerves. Patients with Isaac's syndrome often develop auto-antibodies to voltage-gated potassium channels (VGKCs) which block their function. However, anti-VGKC antibodies are not detected in all patients with Isaac's syndrome, suggesting the existence of another etiology. In this study, we performed immunoscreening using the serum from a patient with Isaac's syndrome and identified the novel gene named Kenae/CCDC125. Expression analysis of Kenae/CCDC125 revealed that its transcript was highly expressed in tissues associated with the immune system, such as the thymus, spleen and bone marrow. In cells stably expressing Kenae/CCDC125, delay in cell motility and deregulation of RhoGTPase (RhoA, Rac1 and cdc42) activity to extracellular stimuli were demonstrated. These results suggest that the novel gene, Kenae/CCDC125, acts as a regulator of cell motility through RhoA, Rac1 and cdc42."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm_00000271"xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm_00000271"xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Ishida J."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Ishida J."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Fukamizu A."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Fukamizu A."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Fujita H."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Nishioka K."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Nishioka K."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Nakajima T."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Fujii R."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Fujii R."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Arimura H."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Arimura H."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Kawahara K."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Kawahara K."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Yamano Y."xsd:string |
| http://purl.uniprot.org/citations/19787194 | http://purl.uniprot.org/core/author | "Yamano Y."xsd:string |