| http://purl.uniprot.org/citations/19788913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19788913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19788913 | http://www.w3.org/2000/01/rdf-schema#comment | "Mu opioid receptors (MOP) are transducers of the pharmacological effects of many opioid drugs, including analgesia and tolerance/dependence. Previously, we observed increased MOP signaling during postnatal development that was not associated with increased MOP or G protein expression. A yeast two-hybrid screen of a human brain cDNA library using the MOP C-terminus as bait identified RanBPM as a potential MOP-interacting protein. RanBPM has been recognized as a multi-functional scaffold protein that interacts with a variety of signaling receptors/proteins. Co-immunoprecipitation studies in HEK293 cells indicated that RanBPM constitutively associates with MOP. Functionally, RanBPM had no effect on MOP-mediated inhibition of adenylyl cyclase, yet reduced agonist-induced endocytosis of MOP. Mechanistically, RanBPM interfered with beta arrestin2-GFP translocation stimulated by MOP but not alpha(1B)-adrenergic receptor activation, indicating selectivity of action. Our findings suggest that RanBPM is a novel MOP-interacting protein that negatively regulates receptor internalization without altering MOP signaling through adenylyl cyclase."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2009.09.048"xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2009.09.048"xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Bianchi E."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Bianchi E."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Toews M.L."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Toews M.L."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Skifter D.A."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Skifter D.A."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Monaghan D.T."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Monaghan D.T."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Murrin L.C."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Murrin L.C."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Talbot J.N."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/author | "Talbot J.N."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/name | "Neurosci. Lett."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/name | "Neurosci. Lett."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/pages | "154-158"xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/pages | "154-158"xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/title | "Regulation of mu opioid receptor internalization by the scaffold protein RanBPM."xsd:string |
| http://purl.uniprot.org/citations/19788913 | http://purl.uniprot.org/core/title | "Regulation of mu opioid receptor internalization by the scaffold protein RanBPM."xsd:string |