| http://purl.uniprot.org/citations/19797079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19797079 | http://www.w3.org/2000/01/rdf-schema#comment | "Before entering translation, preribosomal particles undergo sequential late maturation steps. In the case of pre-60S particles, these steps involve the release of shuttling maturation factors and transport receptors. In this study, we report a new maturation step in the 60S biogenesis pathway in budding yeast. We show that efficient release of the nucleolar/nuclear ribosomal-like protein Mrt4 (homologous to the acidic ribosomal P-protein Rpp0) from pre-60S particles requires the highly conserved protein Yvh1, which associates only with late pre-60S particles. Cell biological and biochemical analyses reveal that Mrt4 fails to dissociate from late pre-60S particles in yvh1Delta cells, inducing a delay in nuclear pre-ribosomal RNA processing and a pre-60S export defect in yvh1Delta cells. Moreover, we have isolated gain of function alleles of Mrt4 that specifically bypass the requirement for Yvh1 and rescue all yvh1Delta-associated phenotypes. Together, our data suggest that Yvh1-mediated release of Mrt4 precedes cytoplasmic loading of Rpp0 on pre-60S particles and is an obligatory late step toward construction of translation-competent 60S subunits."xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200904111"xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/author | "Panse V.G."xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/author | "Kemmler S."xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/author | "Occhipinti L."xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/author | "Veisu M."xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/pages | "863-880"xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/title | "Yvh1 is required for a late maturation step in the 60S biogenesis pathway."xsd:string |
| http://purl.uniprot.org/citations/19797079 | http://purl.uniprot.org/core/volume | "186"xsd:string |
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