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http://purl.uniprot.org/citations/19799794http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19799794http://www.w3.org/2000/01/rdf-schema#comment"

Background

Adult-type hypolactasia, the physiological decline of lactase some time after weaning, was previously associated with the LCT -13910C>T polymorphism worldwide except in Africa. Lactase non-persistence is the most common phenotype in humans, except in northwestern Europe with its long history of pastoralism and milking. We had previously shown association of LCT -13910C>T polymorphism with adult-type hypolactasia in Brazilians; thus, we assessed its frequency among different Brazilian ethnic groups.

Methods

We investigated the ethnicity-related frequency of this polymorphism in 567 Brazilians [mean age, 42.1 +/-16.8 years; 157 (27.7%) men]; 399 (70.4%) White, 50 (8.8%) Black, 65 (11.5%) Brown, and 53 (9.3%) Japanese-Brazilian. DNA was extracted from leukocytes; LCT -13910C>T polymorphism was analyzed by PCR-restriction fragment length polymorphism.

Results

Prevalence of the CC genotype associated with hypolactasia was similar (57%) among White and Brown groups; however, prevalence was higher among Blacks (80%) and those of Japanese descent (100%). Only 2 (4%) Blacks had TT genotype, and 8 (16%) had the CT genotype. Assuming an association between CC genotype and hypolactasia, and CT and TT genotypes with lactase persistence, 356 (62.8%) individuals had hypolactasia and 211 (37.2%) had lactase persistence. The White and Brown groups had the same hypolactasia prevalence (approximately 57%); nevertheless, was 80% among Black individuals and 100% among Japanese-Brazilians (P < 0.01).

Conclusion

The lactase persistence allele, LCT -13910T, was found in about 43% of both White and Brown and 20% of the Black Brazilians, but was absent among all Japanese Brazilians studied."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.org/dc/terms/identifier"doi:10.1186/1475-2891-8-46"xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/author"Silva J.M."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/author"Carrilho F.J."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/author"Santos A.F."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/author"Monteiro M.S."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/author"Mattar R."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/author"Villares C.A."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/name"Nutr J"xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/pages"46"xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/title"Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups."xsd:string
http://purl.uniprot.org/citations/19799794http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/19799794http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19799794
http://purl.uniprot.org/citations/19799794http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19799794
http://purl.uniprot.org/uniprot/#_P09848-mappedCitation-19799794http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19799794
http://purl.uniprot.org/uniprot/#_Q45V77-mappedCitation-19799794http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19799794
http://purl.uniprot.org/uniprot/Q45V77http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19799794
http://purl.uniprot.org/uniprot/P09848http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19799794