| http://purl.uniprot.org/citations/19800275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19800275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19800275 | http://www.w3.org/2000/01/rdf-schema#comment | "Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse biological processes. Here, we combine deep-sequencing and genetic approaches to explore the biogenesis and function of endo-siRNAs in C. elegans. We describe conditional alleles of the Dicer-related helicase, drh-3, that abrogate both RNA interference and the biogenesis of endo-siRNAs, called 22G-RNAs. DRH-3 is a core component of RNA-dependent RNA polymerase (RdRP) complexes essential for several distinct 22G-RNA systems. We show that, in the germline, one system is dependent on worm-specific AGOs, including WAGO-1, which localizes to germline nuage structures called P granules. WAGO-1 silences certain genes, transposons, pseudogenes, and cryptic loci. Finally, we demonstrate that components of the nonsense-mediated decay pathway function in at least one WAGO-mediated surveillance pathway. These findings broaden our understanding of the biogenesis and diversity of 22G-RNAs and suggest additional regulatory functions for small RNAs."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.09.020"xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2009.09.020"xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Carrington J.C."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Carrington J.C."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Gu W."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Gu W."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Duan S."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Duan S."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Moresco J.J."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Moresco J.J."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Yates J.R."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Yates J.R."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Chen C.C."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Fahlgren N."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Fahlgren N."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Kasschau K.D."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Kasschau K.D."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |
| http://purl.uniprot.org/citations/19800275 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |