| http://purl.uniprot.org/citations/19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19801543 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of cell function by fibroblast growth factors (FGFs) classically occurs through a dual receptor system of a tyrosine kinase receptor (FGFR) and a heparan sulfate proteoglycan co-receptor. Mutations in some consensus N-glycosylation sites in human FGFR result in skeletal disorders and craniosynostosis syndromes, and biophysical studies in vitro suggest that N-glycosylation of FGFR alters ligand and heparan sulfate binding properties. The evolutionarily conserved FGFR signaling system of Caenorhabditis elegans has been used to assess the role of N-glycosylation in the regulation of FGFR signaling in vivo. The C. elegans FGF receptor, EGL-15, is N-glycosylated in vivo, and genetic substitution of specific consensus N-glycosylation sites leads to defects in the maintenance of fluid homeostasis and differentiation of sex muscles, both of which are phenotypes previously associated with hyperactive EGL-15 signaling. These phenotypes are suppressed by hypoactive mutations in EGL-15 downstream signaling components or activating mutations in the phosphatidylinositol 3-kinase pathway, respectively. The results show that N-glycans negatively regulate FGFR activity in vivo supporting the notion that mutation of N-glycosylation sites in human FGFR may lead to inappropriate activation of the receptor."xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.058925"xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/author | "Fernig D.G."xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/author | "Harries J.C."xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/author | "Duchesne L."xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/author | "Kinnunen T.K."xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/author | "Polanska U.M."xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/pages | "33030-33039"xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/title | "N-Glycosylation regulates fibroblast growth factor receptor/EGL-15 activity in Caenorhabditis elegans in vivo."xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19801543 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19801543 |
| http://purl.uniprot.org/citations/19801543 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19801543 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AVM0-mappedCitation-19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AYK2-mappedCitation-19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AYL0-mappedCitation-19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ASS4-mappedCitation-19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ATB0-mappedCitation-19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ATB5-mappedCitation-19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/#_Q10656-mappedCitation-19801543 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/A0A0K3AVM0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/Q10656 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19801543 |
| http://purl.uniprot.org/uniprot/A0A0K3ATB5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19801543 |