| http://purl.uniprot.org/citations/19801577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19801577 | http://www.w3.org/2000/01/rdf-schema#comment | "Prokineticin-1 (PROK1) is a multifunctional secreted protein which signals via the G-protein coupled receptor, PROKR1. Previous data from our laboratory using a human genome survey microarray showed that PROK1-prokineticin receptor 1 (PROKR1) signalling regulates numerous genes important for establishment of early pregnancy, including the cytokine interleukin (IL)-11. Here, we have shown that PROK1-PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua via the calcium-calcineurin signalling pathway in a guanine nucleotide-binding protein (G(q/11)), extracellular signal-regulated kinases, Ca(2+) and calcineurin-nuclear factor of activated T cells dependent manner. Conversely, treatment of human decidua with a lentiviral miRNA to abolish endogenous PROK1 expression results in a significant reduction in IL-11 expression and secretion. Importantly, we have also shown a regulatory role for the regulator of calcineurin 1 isoform 4 (RCAN1-4). Overexpression of RCAN1-4 in PROKR1 Ishikawa cells using an adenovirus leads to a reduction in PROK1 induced IL-11 indicating that RCAN1-4 is a negative regulator in the calcineurin-mediated signalling to IL-11. Finally, we have shown the potential for both autocrine and paracrine signalling in the human endometrium by co-localizing IL-11, IL-11Ralpha and PROKR1 within the stromal and glandular epithelial cells of non-pregnant endometrium and first trimester decidua. Overall we have identified and characterized the signalling components of a novel PROK1-PROKR1 signalling pathway regulating IL-11."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.org/dc/terms/identifier | "doi:10.1093/molehr/gap084"xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/author | "Evans J."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/author | "Critchley H.O."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/author | "Jabbour H.N."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/author | "Sales K.J."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/author | "Cook I.H."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/author | "Maldonado-Perez D."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/name | "Mol Hum Reprod"xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/pages | "158-169"xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/title | "Prokineticin-1 (PROK1) modulates interleukin (IL)-11 expression via prokineticin receptor 1 (PROKR1) and the calcineurin/NFAT signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/19801577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19801577 |
| http://purl.uniprot.org/citations/19801577 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19801577 |
| http://purl.uniprot.org/uniprot/#_A8K3F7-mappedCitation-19801577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801577 |
| http://purl.uniprot.org/uniprot/#_P58294-mappedCitation-19801577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801577 |
| http://purl.uniprot.org/uniprot/#_P20809-mappedCitation-19801577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801577 |
| http://purl.uniprot.org/uniprot/#_Q8TCW9-mappedCitation-19801577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19801577 |
| http://purl.uniprot.org/uniprot/A8K3F7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19801577 |
| http://purl.uniprot.org/uniprot/P20809 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19801577 |
| http://purl.uniprot.org/uniprot/Q8TCW9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19801577 |
| http://purl.uniprot.org/uniprot/P58294 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19801577 |