| http://purl.uniprot.org/citations/19804407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19804407 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-4 is a pleiotropic immunoregulatory cytokine secreted by Th2 subset of CD4(+) Th cells. Several transcription factors (TFs) have been determined with various degrees of certainty to bind the IL-4 promoter and to regulate its expression in human. To investigate the mechanisms responsible for phenotypic effects of the C-33T IL-4 promoter polymorphism, we performed a search of TFs binding to this promoter locus and discriminating the -33C and -33T alleles. In silico searches suggest few factors bind this region. Using an electromobility shift assay we found that Jurkat T cells contained proteins which specifically interacted with oligonucleotide probes, corresponding to the -33 region. Considerable binding differences between C and T alleles were demonstrated using competitive conditions, the proteins bound predominantly with -33C allele. We found that the transcription factor Oct-1 produced the major shifted complex. The binding of Oct-1 was not improved using activated nuclear extracts; however, we observed increases in other shifted complexes upon cell activation. We suppose that Oct-1 occupancy may compete for binding of activator proteins to closely or overlapped binding sites. Our findings suggest that the interplay between Oct-1 and unknown TFs may be responsible for the C-33T polymorphism effects."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1744-313x.2009.00883.x"xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/author | "Olenina L.V."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/author | "Gervaziev Y.V."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/author | "Gervazieva V.B."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/author | "Krasotkina J.V."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/author | "Lupatov A.Y."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/author | "Mazurina S.A."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/name | "Int J Immunogenet"xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/pages | "13-20"xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/title | "Oct-1 is responsible for the C-33T polymorphism effect in the IL-4 promoter."xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/19804407 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19804407 |
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