| http://purl.uniprot.org/citations/19805319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19805319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19805319 | http://www.w3.org/2000/01/rdf-schema#comment | "Peripheral interactions between nociceptive fibers and mast cells contribute to inflammatory pain, but little is known about mechanisms mediating neuro-immune communication. Here we show that metalloproteinase MT5-MMP (MMP-24) is an essential mediator of peripheral thermal nociception and inflammatory hyperalgesia. We report that MT5-MMP is expressed by CGRP-containing peptidergic nociceptors in dorsal root ganglia and that Mmp24-deficient mice display enhanced sensitivity to noxious thermal stimuli under basal conditions. Consistently, mutant peptidergic sensory neurons hyperinnervate the skin, a phenotype that correlates with changes in the regulated cleavage of the cell-cell adhesion molecule N-cadherin. In contrast to basal nociception, Mmp24(-/-) mice do not develop thermal hyperalgesia during inflammation, a phenotype that appears associated with alterations in N-cadherin-mediated cell-cell interactions between mast cells and sensory fibers. Collectively, our findings demonstrate an essential role of MT5-MMP in the development of dermal neuro-immune synapses and suggest that this metalloproteinase may be a target for pain control."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0908507106"xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0908507106"xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Lopez-Otin C."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Lopez-Otin C."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Farinas I."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Farinas I."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Garcia-Suarez O."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Garcia-Suarez O."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Pendas A.M."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Pendas A.M."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Llano E."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Llano E."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Astudillo A."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Astudillo A."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Baamonde A."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Baamonde A."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Belmonte C."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Belmonte C."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Denlinger B.L."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Denlinger B.L."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Folgueras A.R."xsd:string |
| http://purl.uniprot.org/citations/19805319 | http://purl.uniprot.org/core/author | "Folgueras A.R."xsd:string |