| http://purl.uniprot.org/citations/19805900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19805900 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factor binding protein-3 (IGFBP-3) is known to induce apoptosis in an insulin-like growth factor (IGF)-dependent and IGF-independent manner, but the mechanism underlying the IGF-independent effects remains unclear. Polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) is a novel IGFBP-3 binding partner. In this paper, small interference RNA (siRNA) targeting GalNAc-T14 was used to examine whether GalNAc-T14 affects the apoptotic action of IGFBP-3. Using semi-quantitative reverse-transcriptase polymerase chain reaction (RT-PCR) and western blot analysis, we determined that GalNAc-T14 expression was downregulated by the siRNA directed against GalNAc-T14. Apoptosis analysis of IGFBP-3-overexpressing cells treated with siRNA against GalNAc-T14 was performed to determine if GalNAc-T14 was specifically involved in IGFBP-3 signalling. The results, as determined by flow cytometric analysis and caspase-3 assay, showed that the extent of apoptosis induced by IGFBP-increased with RNA interference (RNAi) knockdown of GalNAc-T14. Our data suggest that GalNAc-T14 influences the apoptotic action of IGFBP-3 and might mediate the signalling pathway of IGFBP-3. Experiments to determine the role of GalNAc-T14 in the regulation of apoptosis induced by IGFBP-3 are under way."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12038-009-0045-z"xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Xu D."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Shan Y."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/author | "Zou M."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/name | "J Biosci"xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/pages | "389-395"xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/title | "GalNAc-T14 may be involved in regulating the apoptotic action of IGFBP-3."xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/19805900 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19805900 |
| http://purl.uniprot.org/citations/19805900 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19805900 |
| http://purl.uniprot.org/uniprot/#_B7Z5C5-mappedCitation-19805900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19805900 |
| http://purl.uniprot.org/uniprot/#_Q68VI9-mappedCitation-19805900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19805900 |
| http://purl.uniprot.org/uniprot/#_Q96FL9-mappedCitation-19805900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19805900 |
| http://purl.uniprot.org/uniprot/B7Z5C5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19805900 |
| http://purl.uniprot.org/uniprot/Q68VI9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19805900 |
| http://purl.uniprot.org/uniprot/Q96FL9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19805900 |