| http://purl.uniprot.org/citations/19808251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19808251 | http://www.w3.org/2000/01/rdf-schema#comment | "Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)-infected individuals. However, their role and dynamics during infection remain unknown because of the lack of a suitable small animal model. We have generated human group 1 CD1 transgenic (hCD1Tg) mice that express all three human group 1 CD1 isoforms and support the development of group 1 CD1-restricted T cells with diverse T cell receptor usage. Both mycobacterial infection and immunization with Mtb lipids elicit group 1 CD1-restricted Mtb lipid-specific T cell responses in hCD1Tg mice. In contrast to CD1d-restricted NKT cells, which rapidly respond to initial stimulation but exhibit anergy upon reexposure, group 1 CD1-restricted T cells exhibit delayed primary responses and more rapid secondary responses, similar to conventional T cells. Collectively, our data demonstrate that group 1 CD1-restricted T cells participate in adaptive immune responses upon mycobacterial infection and could serve as targets for the development of novel Mtb vaccines."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20090898"xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Choi H.J."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Nguyen H."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Brenner M.B."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Moody D.B."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Wang C.R."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Dascher C.C."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Colmone A."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Felio K."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/author | "Zimmer M.I."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/pages | "2497-2509"xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/title | "CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://purl.uniprot.org/core/volume | "206"xsd:string |
| http://purl.uniprot.org/citations/19808251 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19808251 |
| http://purl.uniprot.org/citations/19808251 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19808251 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-19808251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808251 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-19808251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808251 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-19808251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808251 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-19808251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808251 |
| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-19808251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808251 |