| http://purl.uniprot.org/citations/19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19808645 | http://www.w3.org/2000/01/rdf-schema#comment | "We demonstrated recently that thioredoxin-interacting protein (Txnip) and the transcription factor Krüppel-like factor 6 (KLF6) were up-regulated in both in vivo and in vitro models of diabetic nephropathy, thus promoting renal injury. Conversely, peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists have been shown to be renoprotective. Hence, this study was undertaken to determine whether Txnip expression is regulated by the transcription factors KLF6 and PPAR-gamma. By using siRNAs and overexpressing constructs, the role of KLF6 and PPAR-gamma in Txnip transcriptional regulation was determined in human kidney proximal tubule cells and in streptozocin-induced diabetes mellitus in Sprague-Dawley rats, in vitro and in vivo models of diabetic nephropathy, respectively. KLF6 overexpression increased Txnip expression and promoter activity, which was inhibited by concurrent exposure to PPAR-gamma agonists. In contrast, reduced expression of KLF6 by siRNA or exposure to PPAR-gamma agonists attenuated high glucose-induced Txnip expression and promoter activity. KLF6-Txnip promoter binding was decreased in KLF6-silenced cells, whereas PPAR-gamma agonists increased PPAR-gamma-Txnip promoter binding. Indeed, silencing of KLF6 increased PPAR-gamma expression, suggesting endogenous regulation of PPAR-gamma expression by KLF6. Moreover, renal KLF6 and Txnip expression increased in rats with diabetes mellitus and was inhibited by PPAR-gamma agonist treatment; however, KLF6 expression did not change in HK-2 cells exposed to PPAR-gamma agonists. Hence, Txnip expression and promoter activity are mediated via divergent effects of KLF6 and PPAR-gamma transcriptional regulation."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2009.090263"xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/author | "Qi W."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/author | "Kelly D.J."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/author | "Pollock C.A."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/author | "Tan C.Y."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/author | "Holian J."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/pages | "1858-1867"xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/title | "Transcription factors Kruppel-like factor 6 and peroxisome proliferator-activated receptor-{gamma} mediate high glucose-induced thioredoxin-interacting protein."xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/19808645 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19808645 |
| http://purl.uniprot.org/citations/19808645 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19808645 |
| http://purl.uniprot.org/uniprot/#_E9PFV2-mappedCitation-19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808645 |
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| http://purl.uniprot.org/uniprot/#_A0A8L2R4Q4-mappedCitation-19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808645 |
| http://purl.uniprot.org/uniprot/#_A0A494C1F9-mappedCitation-19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808645 |
| http://purl.uniprot.org/uniprot/#_B6ZGS2-mappedCitation-19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808645 |
| http://purl.uniprot.org/uniprot/#_A6JLM8-mappedCitation-19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808645 |
| http://purl.uniprot.org/uniprot/#_A6JLM9-mappedCitation-19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808645 |
| http://purl.uniprot.org/uniprot/#_B4DVR8-mappedCitation-19808645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19808645 |