| http://purl.uniprot.org/citations/19811264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19811264 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been suggested that the retinoid X receptor beta (RXRB) gene is a risk factor for Wegener's granulomatosis. We addressed if there is a functional difference in the response to retinoic acid (RA) and vitamin D in Antineutrophil cytoplasmic antibody (ANCA) associated systemic vasculitis (AASV) patients and if this was associated with RXRB genotypes. TNFalpha and IL-10 production were measured in whole blood assay from AASV patients (n = 51) and healthy controls (HC, n = 67). One micromolar of 1,25-(OH)(2) D3, 9-cis RA (9c-RA) or all-trans RA (ATRA) was added to the assay. Genotyping was performed for exons 7 and 2 of the RXRB gene and for a microsatellite in vicinity of the RXRB gene. Lipopolysaccharide (LPS) mediated TNFalpha production and IL-10 were significantly lower in patients. Addition of 1,25-(OH)(2) D3, ATRA or 9c-RA, blunted TNFalpha production, more pronounced in patients. Although all three compounds inhibited IL-10 production significantly in HC, only 1,25-(OH)(2) D3 was found to be effective in patients. Allele distribution of the RXRB microsatellite differed significantly between patients and HC. This was not found for the SNP in exons 2 and 7. Genotype of the latter correlated with the ability of 1,25-(OH)(2) D3 and ATRA to inhibit IL-10 production. We provide immunological evidence for a functional difference in vitamins D and A responsiveness in AASV patients. Since the inhibition of TNFalpha was more effective in patients, vitamin D supplementation might be an additional therapeutical approach."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.org/dc/terms/identifier | "doi:10.1080/08916930902960347"xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Peters A."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Weiss C."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Yard B.A."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Heeringa P."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Prem K."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Buhl B."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Schmitt W.H."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Kallenberg C."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Birck R."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Breedijk A."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/author | "Kalsch A.I."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/name | "Autoimmunity"xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/pages | "467-474"xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/title | "Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplasmic antibody associated vasculitis patients."xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/19811264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19811264 |
| http://purl.uniprot.org/citations/19811264 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19811264 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JKR7-mappedCitation-19811264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811264 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4M5-mappedCitation-19811264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811264 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4N9-mappedCitation-19811264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811264 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z570-mappedCitation-19811264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811264 |