| http://purl.uniprot.org/citations/19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19811436 | http://www.w3.org/2000/01/rdf-schema#comment | "Data regarding polymorphisms of immunoregulatory genes in polyglandular autoimmunity (PGA) are lacking. We have analyzed whether the polymorphism of the proinflammatory cytokine gene TNF-alpha; -308 and mutations of the autoimmune regulator (AIRE) gene were associated with PGA in adults. Sixty-seven patients with PGA and 209 healthy controls were genotyped by multiplex minisequencing with capillary electrophoresis on an ABI PRISM-310 genetic analyzer. HLA DRB1 typing was performed using polymerase-chain-reaction-amplified DNA hybridized with sequence-specific-oligonucleotide probes (PCR-SSO). The TNF-alpha; -308*A allele occurred more frequently in patients (0.269) than in controls (0.163, P = 0.008, P(c) = 0.016). Also, TNF-alpha; -308*A carriers were more frequent in patients than controls (47.8% vs. 31.1%, OR = 1.89, 95%CI = 1.19-3.00). The frequency of the AA genotype was increased in PGA (P = 0.014, P(c) = 0.042). PGA patients with autoimmune thyroid disease and the TNF-alpha; -308 AA genotype showed the highest prevalence of thyroid autoantibodies (TPO, P = 0.04; Tg, P = 0.003). HLA-DRB1*03 and TNF-alpha; -308*A alleles were strongly associated in patients with PGA (87.5%, P(c) < 0.00001). The AIRE R257X and 13bpdel mutations were not observed in patients with PGA. The association of TNF-alpha; -308*A with PGA might be directly or indirectly due to the association with HLA-DRB1*03."xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.org/dc/terms/identifier | "doi:10.1080/08820130902766092"xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/author | "Kaczmarczyk A."xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/author | "Dittmar M."xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/author | "Kahaly G.J."xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/author | "Bischofs C."xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/name | "Immunol Invest"xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/pages | "255-267"xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/title | "The proinflammatory cytokine TNF-alpha -308 AA genotype is associated with polyglandular autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/19811436 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19811436 |
| http://purl.uniprot.org/citations/19811436 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WAE5-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WB88-mappedCitation-19811436 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19811436 |