RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/19815777http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19815777http://www.w3.org/2000/01/rdf-schema#comment"Blood vessels form de novo (vasculogenesis) or upon sprouting of capillaries from preexisting vessels (angiogenesis). With high-resolution imaging of zebrafish vascular development, we uncovered a third mode of blood vessel formation whereby the first embryonic artery and vein, two unconnected blood vessels, arise from a common precursor vessel. The first embryonic vein formed by selective sprouting of progenitor cells from the precursor vessel, followed by vessel segregation. These processes were regulated by the ligand EphrinB2 and its receptor EphB4, which are expressed in arterial-fated and venous-fated progenitors, respectively, and interact to orient the direction of progenitor migration. Thus, directional control of progenitor migration drives arterial-venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.org/dc/terms/identifier"doi:10.1126/science.1178577"xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Shokat K.M."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Stainier D.Y."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Huisken J."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Feldman M.E."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Wang R.A."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Houseman B.T."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Herbert S.P."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/author"Kim T.N."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/pages"294-298"xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/title"Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation."xsd:string
http://purl.uniprot.org/citations/19815777http://purl.uniprot.org/core/volume"326"xsd:string
http://purl.uniprot.org/citations/19815777http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19815777
http://purl.uniprot.org/citations/19815777http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19815777
http://purl.uniprot.org/uniprot/O73874#attribution-38C707412EEA24DD32CAF5DEE892AFE4http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19815777
http://purl.uniprot.org/uniprot/O73875#attribution-38C707412EEA24DD32CAF5DEE892AFE4http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19815777
http://purl.uniprot.org/uniprot/Q9I9L0#attribution-38C707412EEA24DD32CAF5DEE892AFE4http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19815777
http://purl.uniprot.org/uniprot/Q5MD89#attribution-38C707412EEA24DD32CAF5DEE892AFE4http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19815777
http://purl.uniprot.org/uniprot/O73682#attribution-38C707412EEA24DD32CAF5DEE892AFE4http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19815777
http://purl.uniprot.org/uniprot/A0A8M9PWK7#attribution-38C707412EEA24DD32CAF5DEE892AFE4http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19815777
http://purl.uniprot.org/uniprot/Q90Y46#attribution-38C707412EEA24DD32CAF5DEE892AFE4http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19815777